Greene County Virginia is part of the Virginia Department of Transportation's (VDOT) Culpeper District. The district encompasses the counties of Albemarle, Culpeper, Fauquier, Fluvanna, Greene, Louisa, Madison, Orange and Rappahannock, and the independent City of Charlottesville.
Greene County is centrally located along two major transportation corridors: US 29 (a major north/south highway) and US 33 (a major east/west highway). Greene is approximately 18 miles north of Charlottesville, 6 miles north of the Charlottesville/Albemarle Airport, 21 miles east of the Shenandoah Valley, 100 miles south of Washington DC, and 78 miles northwest of Richmond, Virginia. Greene is within 20 miles of Interstate 64 and 25 miles of Interstate 81.